The simplest way to activate the runes is to draw them on your body, just from that the runes will be activated.
Usually, if you want the runes to affect you, you draw them on your left side of the body, that is if your left side is the accepting side. If you write with your right hand, usually right side is giving and left is accepting.
Also you can stare at the runes for several minutes without blinking untill you see them become alive, moving or changing.
You can slowly breathe onto the runes and fill them with your energy as you breathe.
A very powerful way to activate runes is by using your own blood. in this case, menstrual blood should not be used!
The best way to activate a runic amulet is with a ritual where you cleanse the space, close it magically from external influences, invite the 4 elements, invite any helping spirits, then activate the runes with the 4 elements and with your blood.